![]() It has been observed that all types of cancer share genetic alterations, especially in the signaling pathways that control cell progression, apoptosis, and cell growth. Įach genotypic and phenotypic change gives way to alterations in the tumor microenvironment and tumor progression. Phenotypically, it starts with early tissue alterations known as hyperplasia it then progresses to dysplasia, cancer in situ, and finally to invasive cancer that can spread to tissues near and far through the lymphatic and blood systems and metastasize. In general, CC is defined as a multi-stage process involving the uncontrolled proliferation of malignantly transformed cells. However, it still causes a high number of deaths among vulnerable populations of women. Diagnostic tests such as Pap smears and viral DNA analysis, and the development of vaccines against different genotypes of human papillomavirus (HPV), have significantly contributed to reducing the incidence of CC. The present review is an update on the proteomic study of CC.Ĭervical cancer (CC) is the second most common form of cancer in women living in developing countries. Detecting pathologies in their earliest stages can significantly improve a patient’s survival rate, prognosis, and recurrence. However, several cervical carcinogenesis mechanisms are still unclear. Proteomic analysis of biological samples of patients with different grades of cervical intraepithelial neoplasia (CIN) and CC has served to elucidate the pathways involved in the development and progression of cancer and identify cervical proteins associated with CC. The cluster of differential molecular profiles in the genome, the transcriptome, or the proteome is analyzed in the disease, and it is called the molecular signature of cancer. Differential expression analysis using high-throughput techniques applied to biological samples allows determining the physiological state of normal cells and the changes produced by cancer development. Thus, it is essential to deepen our knowledge about the molecular pathogenesis of CC and propose new therapeutic targets and new methods to diagnose this disease in its early stages. Particularly, cervical cancer (CC) is still the second leading cause of cancer death in women from developing countries. Cancer is one of the leading public health issues worldwide, and the number of cancer patients increases every day. ![]()
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